Aamulehti julkaisi 29.3.12 kirjoitukseni Lohikäärme vaatii hoitoa. Siitä on kirvonnut keskustelu, mitä toivoinkin juttua kirjoittaessani. Myös Kansan Uutiset kirjoitti aiheesta 5.4.12 (Hormonihoidosta nousi kohu),  Kansan Uutisten verkkosivuilla tosin keskustelu on ollut vielä ainakin vähäistä. Keskustelun kuluessa muutama asiantuntija on väittänyt, että mielipiteeni hormonihoidon haitoista ja hyödyistä eivät perustu tutkimuksiin.  Tässä päällimmäiset lääketieteelliset viitteet, joihin mielipiteeni hormonikorvaushoidosta liittyvät.

Abu-Taha M. Rius C. Hermenegildo C. Noguera I. Cerda-Nicolas JM. Issekutz AC. Jose PJ. Cortijo J. Morcillo EJ. Sanz MJ. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. Journal of Immunology 2009;183:1393-402:

Stadberg E, Mattsson LA, Milsom I. The prevalence and severity of climacteric symptoms and the use of different treatment regimens in a Swedish population. Acta Obstet Gynecol Scant 1997;76:442-8.

Birge SJ. Practical strategies for the diagnosis and treatment of Alzheimer’s disease. Clin Geriatr 1999;7:56-74.

Mikkola T. Vaihdevuosien hormonihoito – miksi hyvät uutiset eivät ylitä uutiskynnystä? Duodecim 2007;123:2049-50.

Karjalainen Anna. Effect of estrogen replacementi therapy on metabolic risk factors for cardiovascular diseases in hysterectomized postmenpausal women.  Acta Universitatis Ouluensis. D no. 773. Oulu: Oulun yliopisto 2003 91 s. + liitteet. Väitöskirja.

Salpeter SR. Walsh JM. Greyber E. Salpeter EE. Brief report: Coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis. Journal of General Internal Medicine. 2006;21:363-6.

Szmuilowicz EM, Stuentel CA, Seely EW. Influence of menopause on diabetes and diabetes risk.  Nature Reviews Endocrinology 2009;5:553-8.

Pentti K, Tuppurainen M, Honkanen R, ym. Hormone therapy protects from diabetes: the Kuopio Osteoporosis Risk Factor and Prevention Study. European Journal of Endocrinology 2009;160:979-83.

Karim R, Mack WJ, Lobo RA, Hwang J, Liu C, Liu C, Sevanian A, Hodis HN. Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial. Menopause 2005;12;366-73.

Karim R. Hodis HN. Stanczyk FZ. Lobo RA. Mack WJ. Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women.  Journal of Clinical Endocrinology & Metabolism 2008;93:131-8.

Basurto L. Saucedo R. Ochoa R. Hernandez M. Zarate A. Hormone replacement therapy with transdermal estradiol lowers insulin-cortisol and lipoproteins levels in postmenopausal women. Ginecologia y Obstetricia de Mexico 2002;70:491-5.

Sumino H, Ichikawa S, Ohyama Y, Takahashi T, Saito Y, Nakamura T, Kanda T, Kurabayshi M. Effect of transdermal hormone replacement therapy on the monocyte chemoattractant protein-1 concentrations and other vascular inflammatory markers and on endothelial function in postmenopausal women. The American Journal of Cardiology 2005;96:148-53.

Carlsten H.   Immune responses and bone loss: the estrogen connection.  Immunological Reviews. 2005;208:194-206.

Yang YH. Ngo D. Jones M. Simpson E. Fritzemeier KH. Morand EF.  Endogenous estrogen regulation of inflammatory arthritis and cytokine expression in male mice, predominantly via estrogen receptor alpha.  Arthritis & Rheumatism 2010;62:1017-25.

Roman-Blas JA, Castaneda S, Largo R, Herrero-Beaumont G.  Osteoarthritis associated with estrogen deficiency. Arthritis Research & Therapy 2009;11:241.

Zandi PP, Carlson MC, Plassman BL, Welsh-Bohmer KA, Mayer LS, Steffens DC, Breitner JCS. Hormone Replacement Therapy and Incidence of Alzheimer Disease in Older Women: The Cache County Study. JAMA 2002;288:2123-9.

Phung TK, Waltoft BL, Laursen TM, Settnes A, Kessing LV, Mortensen PB, Waldemar G. Hysterectomy, oophorectomy and risk of dementia: a nationwide historical cohort study.  Dementia & Geriatric Cognitive Disorders 2010;30:43-50.

Schupf N, Winsten S, Patel B, Pang D, Ferin M, Zigman WB, Silverman W, Mayeux R. Bioavailable estradiol and age at onset of Alzheimer’s disease in postmenopausal women with Down syndrome. Neuroscience Letters 2006;406:298-302.

Rehman HU. Masson EA. Neuroendocrinology of female aging. Gender Medicine 2005;2:41-56.

Ball LJ, Birge SJ. Prevention of brain aging and dementia.  Clinics in Geriatric Medicine 2002;18:485-503.

Prihartono N, Palmer JR, Louik C, Shapiro S, Rosenberg L. A case control study of use of postmenopausal female hormone supplements in relation to the risk of large bowel cancer. Cancer Epidemiology, Biomarkers & Prevention 2000;9:443-7.

Fernandez E, La Vecchia C, Braga C, Talamini R, Negri E, Parazzini F, Franceschi S. Hormone replacement therapy and risk of colon and rectal cancer. Cancer Epidemiology, Biomarkers & Prevention 1998;7:329-33.

Jochems C, Islander U, Erlandsson M, Engdahl C, Lagerquist M, Gjertsson I, Ohlsson C, Holmdahl R, Carlsten H.  Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis. BMC Musculoskeletal Disorders 2010;11:284.

Richette P. Corvol M. Bardin T.  Estrogens, cartilage, and osteoarthritis. Joint, Bone, Spine: Revue du Rhumatisme 2003;70:257-62.

Olie V, Plu-Bureau G, Conard J, Horellou MH, Canonico M, Scarabin PY. Hormone therapy and recurrence of venous thromboembolism among posmenopausal women. Menopause 2011;18:288-93.

Jochems C. Islander U. Erlandsson M. Verdrengh M. Ohlsson C. Carlsten H. Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation. Arthritis Research & Therapy 2005;7:837-43.

Naessen T, Lindmark B, Larsen HC.  Hormone therapy and postural balance in elderly women. Menopause 2007;14:1020-4.

Olie V, Canonico M, Scarabin PY. Postmenopausal hormone therapy and venous thromboembolism. Thrombosis Research 2011;127:26-9.

Canonico M, Fournier A, Carcaillon L, Olie V, Plu-Bureau G, Oger E, Mesrine S, Boutron-Ruault MC, Clavel-Chapelon F, Scarabin PY.  Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism: results from the E3N cohort study.  Arteriosclerosis, Thrombosis & Vascular Biology 2010;30:340-5.

Scarabin P-Y, Oger E, Plu-Bureau G.  Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet 2003;362:428-32.

Carlsten H.   Immune responses and bone loss: the estrogen connection.  Immunological Reviews. 2005;208:194-206.

Talamini R, Franceschi S, Dal Maso L, Negri E, Conti E, Filiberti R, Montella M, Nanni O, La Vecchia C. The influence of reproductive and hormonal factors on the risk of colon and rectal cancer in women.  European Journal of Cancer 1998;34:1070-6.

Nanda K, Bastian LA, Hasselblad V, Simel DL. Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis. Obstetrics & Gynecology 1999;93:880-8.

Salzman C. Pharmacologic Treatment of Disturbed Sleep in the Elderly. Harvard Review of Psychiatry 2008;16:271-8.

Polo-Kantola P. Sleep and menopause. Women’s Health 2007;3:99-106.

Moriyama CK, Oneda B, Bernardo FR, Cardoso CG Jr, Forjaz CL, Abrahao SB, Mion D Jr, Fonseca AM, Tinucci T. A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women.  Menopause 2008;15:613-8.

Berg G, Gottwall T, Hammar M, Lindgren R. Climacteric symptoms among women aged 60–62 in Linköping, Sweden, in 1986. Maturitas 1988;10:193-9.

Rödström K, Bengtsson C,  Lissner L, Milsom I, Sundh V, Björkelund C. A longitudinal study of the treatment of hot flushes: the population study of women in Gothenburg during a quarter of a century. Menopause 2002;9:156-61.

Schnatz PF, Nudy M, O’Sullivan DM, Ethun K, Appt SE, Clarkson TB. Identification of a mechanism for increased cardiovascular risk among individuals with low vitaminen D concentrations. Menopause 2011;18:994-1000.

Santen RJ, Allred DC, Ardoin ADF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH. Scientific Statement: Postmenopausal Hormone Therapy. Endocrine Reviews, June 2010, 31(3):396–406.

Lyytinen H, Pukkala E, Ylikorkala O. Breast cancer risk in postmenopausal women using estradiol-progestogen therapy. Obstet Gynecol 2009;113:65-73.

Suzuki S. Brown CM. Wise PM.  Mechanisms of neuroprotection by estrogen. Endocrine 2006;29:209-15.

Suzuki S. Brown CM. Wise PM. Neuroprotective effects of estrogens following ischemic stroke. Frontiers in Neuroendocrinology 2009;30:201-11.

Wise PM. Suzuki S. Brown CM. Estradiol: a hormone with diverse and contradictory neuroprotective actions.  Dialogues in Clinical Neuroscience 2009;11:297-303.

Reding KW, Doody DR, McTiernan A, Hsu L, Davis S, Daling JR, Porter PL, Malone KE. Age-related variation in the relationship between menopausal hormone therapy and the risk of dying from breast cancer. Breast Cancer Research & Treatment 2011;126:749-61.

Schairer C, Adami HO, Hoover R, Persson I. Cause specific mortality in women receiving hormone replacement therapy. Epidemiology 1997;8:59-65.

Willis DB, Calle EE, Miracle-MaMahill HL, Heath CW. Estrogen replacement therapy and risk of fatal breast cancer in a prospective cohort of postmenopausal women in the United States. Cancer Causes Control 1996;7:449-57.

Erkkola R.  Suomen Lääkärilehti 27-29 / 2004 (vsk 59): 2732-35.

Long CY. Liu CM. Hsu SC. Chen YH. Wu CH. Tsai EM.  A randomized comparative study of the effects of oral and topical estrogen therapy on the lower urinary tract of hysterectomized postmenopausal women. Fertility & Sterility 2006;85:155-60.

Robinson D, Cardozo L. Overactive bladder in the female patient: the role of estrogens. Current Urology Reports 2002;3:452-7.

Nelken RS, Ozel BZ, Leegant AR, Felix JC, Mishell DR Jr. Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder.   Menopause 2011;18:962-6.

Long MD, Martin CF, Galanko JA, Sandler RS. Hormone Replacement Therapy, Oral Contraceptive Use, and Distal Large Bowel Cancer: A Population-Based Case–Control Study. American Journal of Gastroenterology 2010;105:1843–50.

Rossouw JE., Prentice RL, Manson JE, et al.  Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause.  JAMA 2007;297:1465-77.

Mesalic L, Tupkovic E, Kendic S, Balic D. Correlation between hormonal and lipid status in women in menopause. Bosnian Journal of Basic Medical Sciences 2008;8:188-92.

Jick S, Hagberg K, Kaye J, Jick H. Postmenopausal estrogen- containing hormone therapy and the risk of breast cancer. Obstet Gynecol 2009;113:74-80.

Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH. Scientific Statement: Postmenopausal Hormone Therapy. Endocrine Reviews 2010;31:396–406.

Salpeter S. Mortality Associated with Hormone Replacement Therapy in Younger and Older Women. Journal of General Internal Medicine. 2006;21:401.

Salpeter SR, Walsh JM, Greyber E, Ormiston TM, Salpeter EE. Mortality associated with hormone replacement therapy in younger and older women: a meta-analysis. Journal of General Internal Medicine 2004;19:791-804.

Studd J. Ten reasons to be happy about hormone replacement therapy: a guide for patients.  Menopause International 2010;16:44-6.

Salpeter SR, Buckley NS, Liu H, Salpeter EE. The cost-effectiveness of hormone therapy in younger and older postmenopausal women.   American Journal of Medicine 2009;122;42-52.

Salpeter SR. Cheng J. Thabane L. Buckley NS. Salpeter EE. Bayesian meta-analysis of hormone therapy and mortality in younger postmenopausal women. American Journal of Medicine 2009;122:1016-22.

Salpeter SR. Walsh JM. Ormiston TM. Greyber E. Buckley NS. Salpeter EE. Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women. Diabetes, Obesity & Metabolism 2006;8:538-54.

Gilliver SC. Sex steroids as inflammatory regulators.  Journal of Steroid Biochemistry & Molecular Biology 2010;120:105-15.

Wise PM, Suzuki S, Brown CM. Estradiol: a hormone with diverse and contradictory neuroprotective actions. Dialogues in Clinical Neuroscience 2009;11:297-303.